A massive dose of allogeneic platelet gel for wound hemostatic therapy on patients with giant thoracic aortic aneurysm: report of 2 cases

Jianjun Wu; Bin Jiang; Renxue Xiang; Ronghui Shi; Changsheng He; Kang Yang; Xin Cui; Shuming Zhao

A massive dose of allogeneic platelet gel for wound hemostatic therapy on patients with giant thoracic aortic aneurysm: report of 2 cases

Received:February 25, 2021 Revised:March 24, 2021

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DOI：10.46701/BG.2021012021105

KeyWord:allogeneic platelet platelet-rich plasma platelet gel thoracic aortic aneurysms

Author	Institution
Jianjun Wu	Department of Blood Transfusion, GuiQian International General Hospital, Guiyang, Guizhou 550018, China
Bin Jiang	Department of Cardiothoracic Surgery, GuiQian International General Hospital, Guiyang, Guizhou 550018, China
Renxue Xiang	Department of Blood Transfusion, GuiQian International General Hospital, Guiyang, Guizhou 550018, China
Ronghui Shi	Department of Blood Transfusion, GuiQian International General Hospital, Guiyang, Guizhou 550018, China
Changsheng He	Department of Blood Transfusion, GuiQian International General Hospital, Guiyang, Guizhou 550018, China
Kang Yang	Department of Cardiothoracic Surgery, GuiQian International General Hospital, Guiyang, Guizhou 550018, China
Xin Cui	Guizhou Province Blood Center, Guiyang, Guizhou 550002, China
Shuming Zhao	Department of Blood Transfusion, GuiQian International General Hospital, Guiyang, Guizhou 550018, China

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Abstract:

Autologous platelet-rich plasma (PRP) or platelet gel (PG) has been widely used in clinical treatment. Allogeneic PRP or PG may also become a safe and effective alternative method. In this study, two cases with giant thoracic aortic aneurysm were reported where massive doses of allogeneic PG were used to spray the thoracic aortic aneurysm wall suture wrapped in artificial blood vessels, tumors blood vessel wall anastomotic site, and incision site of surgical operation. The volumes of 220 mL and 250 mL PG were applied on two patients respectively, to clot bleeding and decrease the mediastinal and pericardial drainage days after operation. The drainage tubes were pulled out on the 4^th day after operation. The patients were transferred from ICU to a cardiothoracic surgery ward on the 4^th and 5^th day respectively. This study suggests that allogeneic platelet concentrate, as a source of PRP to prepare PG, may be used to promote and help the clotting and wound healing on surgical operation.