Distribution of HLA class Ⅰ and class Ⅱ haplotypes in Chinese Han population based on family segregation
Received:March 19, 2021  Revised:April 26, 2021
View Full Text  View/Add Comment  Download reader
DOI:10.46701/BG.2021012021109
KeyWord:HLA polymorphism  allele frequency  haplotype frequency  family segregation
              
AuthorInstitution
Lijun Wang Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China
Wei Li Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China
Dongmei Wang Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China
Na Liu Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China
Yanjun Jia Department of HLA, Beijing Red Cross Blood Center, Beijing 100088, China
Hits: 1280
Download times: 2945
Abstract:
      HLA haplotype analysis has important application value in human population genetics, anthropological research and HLA matching transplantation. Based on HLA-A, -B, -C, -DRB1 and -DQB1 genotyping data from 663 families including 663 leukemia patients and 991 related donors, the allele frequency (AF) and haplotype frequency (HF) of two-, three- and five-locus haplotype distribution patterns in the Chinese Han population were determined by family segregation. A total of 38 alleles at A locus, 75 alleles at B locus, 35 alleles at C locus, 53 alleles at DRB1 locus and 22 alleles at DQB1 locus were discovered in this population. The frequencies of these alleles were basically consistent with those of previous reports except for some tiny differences. The study found 11 A-C, 15 C-B, 4 B-DRB1 and 11 DRB1-DQB1 two-locus haplotypes with a frequency over 2%. The number of A-C-B and A-B-DRB1 three-locus haplotype with a frequency over 1% were 11 and 3 respectively. The most common HLA-A-C-B-DRB1-DQB1 haplotype (HF>1%) were A*3001-C*0602-B*1302-DR*0701-DQ*0202 (4.30%), A*0207-C*0102-B*4601-DR*0901-DQ*0303 (3.07%), A*3303-C*0302-B*5801-DR*0301-DQ*0201 (1.49%) and A*1101-C*0102-B*4601-DR*0901-DQ*0303 (1.01%). The results are helpful for finding matching donors for hematopoietic stem cell transplant patients and also contribute to transplant immunology, HLA-related diseases, research of human genetics and other fields.
Close