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| Screening of tumor-targeting peptides for diagnosis and therapy through phage display technology |
| Received:February 02, 2021 Revised:March 24, 2021 |
| View Full Text View/Add Comment Download reader |
| DOI：10.46701/BG.2021012021103 |
| KeyWord:tumor-targeting peptide phage display technology diagnosis drug discovery |
| Author | Institution |
| Zhiruo Song |
Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu 211166, China |
| Yufeng Zhang |
Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu 211166, China |
| Yuanjie Zhu |
Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu 211166, China;Key Laboratory of Antibody Techniques of National Health Commission, Nanjing Medical University, Nanjing, Jiangsu 211166, China |
| Mingming Zhang |
Key Laboratory of Antibody Techniques of National Health Commission, Nanjing Medical University, Nanjing, Jiangsu 211166, China |
| Xinjian Liu |
Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu 211166, China;Key Laboratory of Antibody Techniques of National Health Commission, Nanjing Medical University, Nanjing, Jiangsu 211166, China |
| Minjun Ji |
Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu 211166, China |
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| Abstract: |
| Phage display technology was introduced by G. Smith in 1985, which is highly effective in the selection of affinity peptides from a library containing billions of display peptides. The obtained peptides show potential efficacy in the development of further clinical applications, especially in tumor treatment. In this review, the basic principles, limits, developments of phage display technology and peptide libraries are introduced. Following that, the amino acid sequence of tumor target peptides for hematological and other systems are discussed. Finally, the application of target peptides in the design of imaging probes and the development of target peptide drugs for diagnosis and therapy are noted. |
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