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| Incidence of unexpected red blood cell antibodies in the north of China |
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| DOI：10.46701/APJBG.20170116001 |
| KeyWord:incidence, alloantibody, alloimmunization, autoantibody |
| Author | Institution |
| Yu-Shiang Lin |
Department of Clinical Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. |
| Jhy-Sheng Chang |
Department of Laboratory Medicine, National Taiwan University Hospital,Taipei City 10002, Taiwan |
| Yan Qiu |
Blood Group Lab, Beijing Red Cross Blood Center; Beijing100088, China. |
| Fu-Hsiung Su |
Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 11042 Taiwan.
School of Medicine, Flinders University, Bedford Park, South Australia 5042, Australia. |
| Yin-Chun Lan |
Department of Clinical Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. |
| Nai-Chung Lee |
Department of Clinical Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. |
| Joyces Wong Lee Mei |
Department of Clinical Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. |
| Daowang Fan |
Blood Group Lab, Beijing Red Cross Blood Center; Beijing100088, China. |
| Tianhong Miao |
Blood Group Lab, Beijing Red Cross Blood Center; Beijing100088, China. |
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| Abstract: |
| This study aimed to investigate the frequency of unexpected antibodies and evaluate the cumulative incidence of additional unexpected antibodies in Beijing. From January 1, 2011 to December 31, 2014, blood samples from 2,095 patients from 98 medical institutes in Beijing were sent to the Beijing Red Cross Blood Center for antibody identification. Of the unexpected antibodies, 29.5% were autoantibodies and 70.5% were alloantibodies. Anti-E was the most prevalent form of allo-antibodies (n = 445), accounting for 52.9% of the Rh system, followed by anti-M (76.6% of the MNS system) and then 142 cases of anti-C,e, 128 cases of anti-E,c, and 113 cases of anti-Lea. The cumulative incidences of additional antibodies were 0.55% (after the first transfusion), 1.82% (second time), 2.33% (fourth time), 3.07% (firth time), and 4.24% (seventh time). Antibody against the Rh system was the most prevalent, followed by antibodies against MNS, Lewis, Kidd, P1, and Duffy. |
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